Structure of PDB 7r50 Chain K

Receptor sequence
>7r50K (length=450) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVA
NMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPV
TLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEARVRDIALSDFVT
APVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAV
DAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIK
AVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTG
VGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGS
WFAGTYESPGDLLFDRDDRPYKESYGMASKRAVFDRARKGLFRMSLDPAR
GGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLP
3D structure
PDB7r50 The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.
ChainK
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.7.1.7: GMP reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP K A51 M53 G300 A301 C303 T305 D336 G337 G338 G359 S360 G386 M387 A388 A50 M52 G290 A291 C293 T295 D326 G327 G328 G349 S350 G376 M377 A378
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003920 GMP reductase activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006166 purine ribonucleoside salvage
GO:0032264 IMP salvage
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7r50, PDBe:7r50, PDBj:7r50
PDBsum7r50
PubMed35338694
UniProtA0QYE8|GUAB1_MYCS2 GMP reductase (Gene Name=guaB1)

[Back to BioLiP]