Structure of PDB 7lps Chain K

Receptor sequence
>7lpsK (length=381) Species: 9606 (Homo sapiens) [Search protein sequence]
INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQT
LPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYRE
EQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSA
VQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMD
RIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAI
QRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGY
VHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTAT
KKDMSPQKFWGLTRSALLPTIPDTEDEISPD
3D structure
PDB7lps Acute pharmacological degradation of Helios destabilizes regulatory T cells.
ChainK
Resolution3.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide K N351 H353 Y355 W386 V388 Q390 A395 H397 N296 H298 Y300 W331 V333 Q335 A340 H342
BS02 ZN K C323 C326 C391 C394 C268 C271 C336 C339
BS03 RN9 K F102 N351 P352 H353 E377 H378 W380 W386 W400 F402 F56 N296 P297 H298 E322 H323 W325 W331 W345 F347
External links
PDB RCSB:7lps, PDBe:7lps, PDBj:7lps
PDBsum7lps
PubMed34035522
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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