Structure of PDB 7kd6 Chain K

Receptor sequence
>7kd6K (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEE
CGDICNCPATVFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNC
SQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKC
KNCHQYVIHNNKCIPECPSGYTMNSSNLLCTP
3D structure
PDB7kd6 Single-chain insulin analogs threaded by the insulin receptor alpha CT domain.
ChainK
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide K L36 L37 F64 F88 F89 F96 R118 K121 L32 L33 F60 F84 F85 F92 R114 K117
External links
PDB RCSB:7kd6, PDBe:7kd6, PDBj:7kd6
PDBsum7kd6
PubMed36181268
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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