Structure of PDB 7joa Chain K

Receptor sequence
>7joaK (length=358) Species: 10090 (Mus musculus) [Search protein sequence]
DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNP
LSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLL
IRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYL
VPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKEC
LKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSS
CFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYER
NNGFPIFD
3D structure
PDB7joa Structural basis of nucleosome-dependent cGAS inhibition.
ChainK
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN K H378 C385 C392 H231 C238 C245
External links
PDB RCSB:7joa, PDBe:7joa, PDBj:7joa
PDBsum7joa
PubMed32913000
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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