Structure of PDB 7enn Chain K

Receptor sequence

>7ennK (length=539) Species: 9606 (Homo sapiens) [Search protein sequence]

AARVQEQDLRQWGLTGIHLRSYQLEGVNWLAQRFHCQNGCILGDEMGLGK
TCQTIALFIYLAGRLNDEGPFLILCPLSVLSNWKEEMQRFAPGLSCVTYA
GDKEERACLQQDLKQESRFHVLLTTYEICLKDASFLKSFPWSVLVVDEAH
RLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFSK
EEVGDFIQRYQDIEKESESASELHKLLQPFLLRRVKAEVATELPKKTEVV
IYHGMSALQKKYYKAILMKKLQNILSQLRKCVDHPYLFDGVEPEPFEVGD
HLTEASGKLHLLDKLLAFLYSGGHRVLLFSQMTQMLDILQDYMDYRGYSY
ERVDGSVRGEERHLAIKNFGQQPIFVFLLSTRAGGVGMNLTAADTVIFVD
SDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLT
NMIIEGGHFEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDAEG
KNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQGRSLRNKG

3D structure

PDB

7enn Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	K	R178 S184 L185 N444	R151 S157 L158 N404
BS02	dna	K	R133 E154 K310 Q312 K320 M372 T373 D394 R402 S420 R422 A423	R106 E127 K270 Q272 K280 M332 T333 D354 R362 S380 R382 A383
BS03	ADP	K	I44 Q50 M73 G74 L75 G76 K77 T78 C79 E113 N429 R457 I458	I17 Q23 M46 G47 L48 G49 K50 T51 C52 E86 N389 R417 I418
BS04	BEF	K	K77 R457	K50 R417

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003678	DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0031491	nucleosome binding
GO:0140566	histone reader activity
GO:0140658	ATP-dependent chromatin remodeler activity
GO:0160004	poly-ADP-D-ribose modification-dependent protein binding

	Biological Process
GO:0006281	DNA repair
GO:0006338	chromatin remodeling
GO:0006974	DNA damage response
GO:0032508	DNA duplex unwinding

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0035861	site of double-strand break

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7enn, PDBe:7enn, PDBj:7enn
PDBsum	7enn
PubMed	34210977
UniProt	Q86WJ1\|CHD1L_HUMAN Chromodomain-helicase-DNA-binding protein 1-like (Gene Name=CHD1L)

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