Structure of PDB 7e8d Chain K

Receptor sequence
>7e8dK (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
RKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNR
MLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRK
GEFVNEYVGELIDKEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGN
YSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLG
NEKTVCRCGASNCSGFLG
3D structure
PDB7e8d Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2.
ChainK
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna K K1124 K1152 K139 K167
BS02 ZN K C1144 C1193 C1198 C159 C208 C213
BS03 ZN K C1016 C1018 C1026 C1032 C31 C33 C41 C47
BS04 ZN K C1026 C1041 C1046 C1052 C41 C56 C61 C67
BS05 SFG K K1073 W1075 T1115 H1116 F1117 Y1118 F1139 N1141 H1142 Y1179 K88 W90 T130 H131 F132 Y133 F154 N156 H157 Y194
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:7e8d, PDBe:7e8d, PDBj:7e8d
PDBsum7e8d
PubMed34782608
UniProtO96028|NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (Gene Name=NSD2)

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