Structure of PDB 7cun Chain K

Receptor sequence
>7cunK (length=588) Species: 9606 (Homo sapiens) [Search protein sequence]
AGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKI
AVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLG
AAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTI
RDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMN
LKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDR
AFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESV
LLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGL
LKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLR
FTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQA
AAPSDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAP
3D structure
PDB7cun Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
ChainK
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN K D78 H79 D184 D62 H63 D168
BS02 ZN K H74 H76 H163 D184 H58 H60 H147 D168
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cun, PDBe:7cun, PDBj:7cun
PDBsum7cun
PubMed33243860
UniProtQ5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

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