Structure of PDB 7c0m Chain K

Receptor sequence
>7c0mK (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]
DAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGV
GLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRN
PKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSP
AVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKP
FYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCR
KDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWD
RKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTK
QIEYERNNEFPVFDEF
3D structure
PDB7c0m Structural basis for the inhibition of cGAS by nucleosomes.
ChainK
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 dna K K285 R300 K427 R499 K129 R144 K271 R343
BS02 ZN K H390 C396 C397 H234 C240 C241
External links
PDB RCSB:7c0m, PDBe:7c0m, PDBj:7c0m
PDBsum7c0m
PubMed32912999
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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