Structure of PDB 6x35 Chain K

Receptor sequence

>6x35K (length=3801) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
LAICCFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHAHSGMYLSCLTT
SRSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDLILVS
VSSERYLHLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLF
HGHMDECLTISPADQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHLRW
GQPLRIRHVTTGRYLALIEDQGLVVVDASKAHTKATSFCFRISKEKLKRD
VEGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDALSL
TRCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRPAGTALPLEGVILS
LQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRL
NVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCALFSNNL
DWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHG
RNHKVLDVLCSLCVCNGVAVCSNQDLITENLLPGRELLLQTNLINYVTSI
RPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSP
YPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHLLAPEDVV
SCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGVKVRFLLG
GRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVGPSR
CLSHTDFVPCPLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK
RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLR
KTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRV
AQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGR
VRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELA
YVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTIIFTLNGEVLMS
DSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQE
GFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRVDGTVDTPPCLR
LTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQEPSCVWVGWVTP
DYHQHDMNFDLTKVRAVTVTMGDNIHSSLKCSNCYMVWGGDFVSHTDLVI
GCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFEL
GKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLRVE
TRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQQFHSHT
LRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLI
SIHLESACRSRRSMLSEYIVPLTPETRAITLFPPRHGLPGVGVTTSLRPP
HHFSAPCFVAALPEAPARLSPSIPLEALRDKALRMLGEAVRDGGQHARDP
VGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVEEGLLQMKL
PESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYGILM
KAFTMTAAETARRTREFRSPPQEQINMLLHFKPLPDEIRQDLLEFHQDLL
THCGIQLQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGEL
LRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGN
IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGRFPKMVTSCCRFLCYFCR
ISRQNQRSMFDHLSYLLENSGSTPLDVAAASVIDNNELALALQEQDLEKV
VSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEE
NANVVVRLLIRKPECFGPALRLLATIEEAIGHAIMSFYAALIDLLGRCAP
EMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPLMSASFVPDHK
ASMVLFLDRVYGIEFLLHVLDVGFEMALALNRYLCLAVLPLITKCAPLFA
MVDSMLHTVYRLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLV
FAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADPR
PVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTH
PMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDL
SGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLT
AKEKARDREKAQELLKFLQMNGYAVTRAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAEFS
VLCRDLYALYPLLIRYVDNNRAHWLTEPNPSAEELFRMVGEIFIYWSKSH
NFKREEQNFVVAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAARRAVVACFRMTPLYNLPTHRA
CNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLH
QLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEESFEEKEMEKQRL
LYQQARLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNADVQ
QKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDG
TVIGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIII
CTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTE
YIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELL
DLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLK
LKDIVGSEAFQDYVTDPRGLISKKDFQKAAAAAAEEFANRFQEPARDIGF
NVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIE
RIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDT
IFEMQAAAAAAAAAAAAAAAAAEVQRVKFLNYLSRNFYTLRFLALFLAFA
INFILLFYKVSDSPPVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYN
CLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFP
SNYWDKFVKRKVLDKHGDIYGRERIAEGLLTWLMSIDVKYQIWKFGVIFT
DNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGK
QLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLF
HMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGL
IIDAFGELRDQQEQVREDMETKCFICGIGSDYFDTTPHRFETHTLEEHNL
ANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQ
L

3D structure

• PDB: 6x35 Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
• Chain: K
• Resolution: 4.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	K	H4976 H4981	H3743 H3748

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Dec 1 19:45:33 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6x35', asym_id = 'K', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6x35', asym_id='K', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6x35', asym_id = 'K'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6x35', asym_id='K')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>