Structure of PDB 6x33 Chain K

Receptor sequence

>6x33K (length=3816) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
LAICCFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHAHSGMYLSCLTT
SRSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDLILVS
VSSERYLHLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLF
HGHMDECLTISPADSDDQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSH
LRWGQPLRIRHVTTGRYLALIEDQGLVVVDASKAHTKATSFCFRISKEKL
KRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDA
LSLTRCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRGSGAPAGTALP
LEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLV
LNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANC
ALFSNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSII
SLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNL
INYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWA
LTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHL
LAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGV
KVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGP
HLVGPSRCLSHTDFVPCHLERIREKLAENIHELWALTRIEQGWTYGPVRD
DNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAED
NLRKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWAR
DRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLG
YGYNIERVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVE
LGADELAYVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTIIFTL
NGEVLMSDSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSSLRFF
AICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRVDGTV
DTPPCLRLTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQEPSCV
WVGWVTPDYHQHDMNFDLTKVRAVTVTMGDNIHSSLKCSNCYMVWGGDFV
SHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQ
NVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMP
NHFLRVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDL
QQFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRA
GYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPRHGLPGVGV
TTSLRPPHHFSAPCFVAALPEAPARLSPSIPLEALRDKALRMLGEAVRDG
GQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVEE
GLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQR
DRYGILMKAFTMTAAETARRTREFRSPPQEQINMLLHFKPLPDEIRQDLL
EFHQDLLTHCGIQLQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQ
YDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENL
MIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLRFPKMVTSCCRF
LCYFCRISRQNQRSMFDHLSYLLENSGGMQGSTPLDVAAASVIDNNELAL
ALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFA
VFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLATIEEAIHLGH
AIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGII
SLPLQIPMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRA
AALALNRYLCLAVLPLITKCAPLFAMVDSMLHTVYRLSRGRSLTKAQRDV
IEECLMALCRYIRPSMLQHLLRRLVFAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAADPRPVETLNVIIPEKLDSFINKFAEYTH
EKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESL
KAMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQAMAEQLAENYHNTWG
RKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAV
TRAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAFSVLCRDLYALYPLLIRYVDNNRAHWL
TEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTED
HSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKL
DEDYLYMAYADIMAKSCHLEESFEEKEMEKQRLLYQQARLHNRGAAEMVL
QMISACKGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQ
SIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVIGEKVMADDEFTQDL
FRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFY
WYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSR
LWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGN
VVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDP
RGLISKKDFQKAAAAAAEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPR
LRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQ
VKESKRQFIFDVVNEKMELFVSFCEDTIFEMQIAAQAAAAAAAAAAAAAA
AAAEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPVYYF
LEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKL
EFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDI
YGRERIAEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAH
LLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKF
YNKMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITF
FFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDYFDT
TPHRFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWD
FFPAGDCFRKQYEDQL

3D structure

• PDB: 6x33 Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
• Chain: K
• Resolution: 4.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	K	H4976 H4981 C5025	H3758 H3763 C3807

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Fri Nov 29 06:49:07 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6x33', asym_id = 'K', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6x33', asym_id='K', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6x33', asym_id = 'K'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6x33', asym_id='K')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>