Structure of PDB 6vz4 Chain K

Receptor sequence

>6vz4K (length=616) Species: 559292 (Saccharomyces cerevisiae S288C)

RKKERNLHLQKINSIIDFIKERQSEQWSRQERCFQFGRLGASLHNQMEKD
EQKRIERTAKQRLAALKSNLLDQTKDTRITQLLRQTNSFLDSLSEAVRAQ
QNDYYEVAHRIKEKIDKQPSILVGGTLKEYQLRGLEWMVSLYNNHLNGIL
ADEMGLGKTIQSISLITYLYEVKKDIGPFLVIVPLSTITNWTLEFEKWAP
SLNTIIYKGTPNQRHSLQHQIRVGNFDVLLTTYEYIIKDKSLLSKHDWAH
MIIDEGHRMKNAQSKLSFTISHYYRTRNRLILTGTPLQNNLPELWALLNF
VLPKIFNSAKTFEDWFNTPFLTEEETLLIIRRLHKVLRPFLLRRLKKEVE
KDLPDKVEKVIKCKLSGLQQQLYQQMLKHNNNKIMQLRKICNHPFVFDEV
EGVVNPSRGNSDLLFRVAGKFELLDRVLPKFKASGHRVLMFFQMTQVMDI
MEDFLRMKDLKYMRLDGSTKTEERTEMLNAFNAPDSDYFCFLLSTRAGGL
GLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTDSVE
EVILERAMQKLDIDGKVIQAGAELDDDELNDTLARSADEKILFDKIDKER
MNQEKEDSEPLGRIRQ

3D structure

• PDB: 6vz4 Structural insights into assembly and function of the RSC chromatin remodeling complex.
• Chain: K
• Resolution: 3.9 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	K	K603 S607 K608 L609 K755 W889 R928 K932	K260 S264 K265 L266 K383 W517 R556 K560
BS02	dna	K	L528 R557 Y578 K761 M816 G839 R846 S866	L185 R214 Y235 K389 M444 G467 R474 S494
BS03	MG	K	D597 E598	D254 E255
BS04	ADP	K	T469 Q474 G498 G500 K501 T502 I503 R903 I904	T126 Q131 G155 G157 K158 T159 I160 R531 I532

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0042393 histone binding
• GO:0140658 ATP-dependent chromatin remodeler activity

External links

• PDB: RCSB:6vz4, PDBe:6vz4, PDBj:6vz4
• PDBsum: 6vz4
• PubMed: 33288924
• UniProt: P32597|STH1_YEAST Nuclear protein STH1/NPS1 (Gene Name=STH1)