Structure of PDB 6veq Chain K

Receptor sequence
>6veqK (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEE
CGDICNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSEC
LGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDL
HHKQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCP
3D structure
PDB6veq A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
ChainK
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide K E141 D142 E137 D138
BS02 peptide K R14 F88 F89 F96 R118 K121 R10 F84 F85 F92 R114 K117
BS03 peptide K L37 F39 R65 L33 F35 R61
External links
PDB RCSB:6veq, PDBe:6veq, PDBj:6veq
PDBsum6veq
PubMed32483339
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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