Structure of PDB 6txc Chain K

Receptor sequence

>6txcK (length=480) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS
FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYF
VQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

6txc Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DTP	K	V156 F157 R372 H376 K377	V44 F45 R253 H257 K258
BS02	DTP	K	R333 R352 K354 N358	R214 R233 K235 N239
BS03	FE	K	H167 H206 D207 D311	H55 H94 D95 D192
BS04	MG	K	D207 H233	D95 H121
BS05	0KX	K	Q149 L150 R164 D207 H215 D311 K312 Y315 D319 R366 Y374	Q37 L38 R52 D95 H103 D192 K193 Y196 D200 R247 Y255
BS06	GTP	K	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS07	GTP	K	Y155 V156 R451	Y43 V44 R332

External links

PDB	RCSB:6txc, PDBe:6txc, PDBj:6txc
PDBsum	6txc
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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