Structure of PDB 6txa Chain K

Receptor sequence

>6txaK (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVINDPIHGHIELHPLLVRIINTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCH
HLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTK
LTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRE
DYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFY
CKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQ
WCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

6txa Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.853 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	XG4	K	V156 F157 R372 H376 K377	V42 F43 R251 H255 K256
BS02	XG4	K	R333 R352 K354 N358	R212 R231 K233 N237
BS03	FE	K	H167 H206 D207 D311	H53 H92 D93 D190
BS04	MG	K	D207 H233	D93 H119
BS05	XG4	K	Q149 L150 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374 Q375	Q35 L36 R50 D93 H101 H119 D190 K191 Y194 D198 R245 Y253 Q254
BS06	CZF	K	K116 V117 I118 N137 R145	K2 V3 I4 N23 R31
BS07	CZF	K	Y155 V156 V378 R451	Y41 V42 V257 R330

External links

PDB	RCSB:6txa, PDBe:6txa, PDBj:6txa
PDBsum	6txa
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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