Structure of PDB 6tnt Chain K

Receptor sequence

>6tntK (length=493) Species: 9606 (Homo sapiens) [Search protein sequence]

NLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTA
QYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLSIKSSICL
LRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKEL
LESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVV
VSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANEL
FYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYG
PAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNS
KLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKA
IGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSA
IGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYI

3D structure

PDB

6tnt Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation.

Chain

Resolution

3.78 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	K	Y242 Y243 F247 P269 E277 A339 H342 A345 L369 Y373 L376 E377 F403 H406 V410 F413 E445 P446 N449 N450 H453 R456 K457 N478 S480 Y487 L491 F514 M518 M525	Y208 Y209 F213 P235 E243 A305 H308 A311 L335 Y339 L342 E343 F369 H372 V376 F379 E411 P412 N415 N416 H419 R422 K423 N444 S446 Y453 L457 F480 M484 M491

Gene Ontology

	Molecular Function
GO:0005515	protein binding

	Biological Process
GO:0007346	regulation of mitotic cell cycle
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent catabolic process
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0051301	cell division
GO:0051445	regulation of meiotic cell cycle
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0141198	protein branched polyubiquitination

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0072686	mitotic spindle

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6tnt, PDBe:6tnt, PDBj:6tnt
PDBsum	6tnt
PubMed	33789095
UniProt	Q13042\|CDC16_HUMAN Cell division cycle protein 16 homolog (Gene Name=CDC16)

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