Structure of PDB 6sh8 Chain K

Receptor sequence

>6sh8K (length=1024) Species: 930945 (Sulfolobus islandicus REY15A)

EFLDYKIIALLHDPPNKAWVITGRARNLTQQLSRKHEKVAKYIINQLFGK
NYSEKVDNADKLASSIDRYLGSIVYKERSLFENRSIFLKNILLSNIQRDI
GNLFPKDKSKLDNLILEYKKLLNVINKTNLILKYQLFYLIYELVWIDSKY
ENTPSDTRNPTHTIFDHLYATAAMMNWILSLEKEAKGYLLGIDTIGVADF
ISKGRKTRDLWISSYLVSALLWYVITWFIEEYGPDVILFPSLRFNQFYAF
YLLEKLRKEGVSEDVIDEIKELITKYIFNGDDLFENLKIPPYPIIPGRIT
LILPGLIREGEEYKKVQDDNCFISKVKERYNEGWRKLIEGLRCYSERKRE
DGFWNLVCRVLKLTEDLLQTTPLNIRVKQVSVTEDEIFNNNKLRSDSWKI
YDNKYRQLVSEFKKSKLVKVTPESRLKLFELTKFDKLPQIGEKSKRGYEF
CTSCGVLPAVVIMPKEDELEKKLIDLGIARDEKDVRSIKNMISPGERLCP
WCLVKRALGAEPRLMRILLLGDLYSVEKIVNEIVSRDVKIEIPSTSDIAS
IKTFEEMIEKKNEICEDLKEEEVCEKPSESVLSMWQWFNKNYYNGINLTI
DPEEYWFSEKRRRYYFSVFRRHRITFPSPYYALVRADSDYLGDLLEGKLT
PYLAGIIDSGDYANISEKKEEVNKLLEEYLVNAGSGSIVDYVKTVLKCIR
ENLNKCSCAEKIYSNEVAKVMFRVNVEKANVEEEVKNSLEYFETILNEGR
IIVTPAWHVSISSALNRGLLVELELVNKHKGFVIYAGGDDLLAMLPVDEV
LDFIKESRRAFAGFGTEKLGNMCLENGFVRINNAYYPSLPIVGRSYSVII
AHYADPLFFVINDSYNLLEEGKEIIRYRVMYNGEYKDAKKDVAIFRYQGL
TSVIPLSLKRPIVSSVSDFNEIASIIDVILELKKRIDEGRISVSLLYDYE
KYKHLIVASDEKYLTEFLVKDWIKRNSLRKHVEFTIDEKLYGVRLTIENY
PIKIPNDLISNIVYTLRIIYGGEK

3D structure

• PDB: 6sh8 Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
• Chain: K
• Resolution: 3.14 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	K	R625 F639 P640 P642 Y960 Y1033 E1036 K1037	R612 F626 P627 P629 Y947 Y1020 E1023 K1024
BS02	ZN	K	C464 C467 C512 C515	C451 C454 C499 C502
BS03	ANP	K	D206 T207 G209 V210 A211 I214 S227 V230 P309 G310 Y798 D803	D193 T194 G196 V197 A198 I201 S214 V217 P296 G297 Y785 D790
BS04	ANP	K	F252 R311 Y653 L654 G655 L658 D802 D803	F239 R298 Y640 L641 G642 L645 D789 D790
BS05	MN	K	D650 S651	D637 S638
BS06	MN	K	D206 T207	D193 T194

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6sh8, PDBe:6sh8, PDBj:6sh8
• PDBsum: 6sh8
• PubMed: 32730741
• UniProt: F0NDX2