Structure of PDB 6s8b Chain K

Receptor sequence

>6s8bK (length=1009) Species: 930945 (Sulfolobus islandicus REY15A)

FLDYKIIALLHDPPNKAWVITGRAAKYIINQLFGKNYSEKVDNADKLASS
IDRYLGSIVYKERSLFENRSIFLKNILLSNIQRDIGNLFPKDKSKLDNLI
LEYKKLLNVINKTNLILKYQLFYLIYELVWIDSKYENTPSDTRNPTHTIF
DHLYATAAMMNWILSLEKEAKGYLLGIDTIGVADFISKGRKTRDLWISSY
LVSALLWYVITWFIEEYGPDVILFPSLRFNQFYAFYLLEKLRKEGVSEDV
IDEIKELITKYIFNGDDLFENLKIPPYPIIPGRITLILPGLIREGEEYKK
VQDDNCFISKVKERYNEGWRKLIEGLRCYSERKREDGFWNLVCRVLKLTE
DLLQTTPLNIRVKQVSVTEDEIFNNNKLRSDSWKIYDNKYRQLVSEFKKS
KLVKVTPESRLKLFELTKFDKLPQIGEKSKRGYEFCTSCGVLPAVVIMPK
EDELEKKLIDLGIARDEKDVRSIKNMISPGERLCPWCLVKRALGAEPRLM
RILLLGDLYSVEKIVNEIVSRDVKIEIPSTSDIASIKTFEEMIEKKNEIC
EDLKEEEVCEKPSESVLSMWQWFNKNYYNGINLTIDPEEYWFSEKRRRYY
FSVFRRHRITFPSPYYALVRADSDYLGDLLEGKLTPYLAGIIDSGDYANI
SEKKEEVNKLLEEYLVNAGSGSIVDYVKTVLKCIRENLNKCSCAEKIYSN
EVAKVMFRVNVEKANVEEEVKNSLEYFETILNEGRIIVTPAWHVSISSAL
NRGLLVELELVNKHKGFVIYAGGDDLLAMLPVDEVLDFIKESRRAFAGFG
TEKLGNMCLENGFVRINNAYYPSLPIVGRSYSVIIAHYADPLFFVINDSY
NLLEEGKEIIRYRVMYNGEYKDAKKDVAIFRYQGLTSVIPLSLKRPIVSS
VSDFNEIASIIDVILELKKRIDEGRISVSLLYDYEKYKHLIVASDEKYLT
EFLVKDWIKRNSLRKHVEFTIDEKLYGVRLTIENYPIKIPNDLISNIVYT
LRIIYGGEK

3D structure

• PDB: 6s8b Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas.
• Chain: K
• Resolution: 2.41 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	K	K458 R459 K478 R625 Y960 K1037	K430 R431 K450 R597 Y932 K1009
BS02	ZN	K	C464 C512 C515	C436 C484 C487
BS03	ANP	K	D206 T207 I208 G209 V210 A211 S227 P309 G310 K429 Y798 D803	D178 T179 I180 G181 V182 A183 S199 P281 G282 K401 Y770 D775
BS04	ANP	K	F252 R311 D650 D652 Y653 G655 L658 D803 K885 K903	F224 R283 D622 D624 Y625 G627 L630 D775 K857 K875
BS05	MN	K	D650 S651	D622 S623
BS06	MN	K	D206 T207	D178 T179

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6s8b, PDBe:6s8b, PDBj:6s8b
• PDBsum: 6s8b
• PubMed: 32730741
• UniProt: F0NDX2