Structure of PDB 6q6h Chain K

Receptor sequence

>6q6hK (length=518) Species: 9606 (Homo sapiens) [Search protein sequence]

NLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTA
QYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDSIKSSIC
LLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKE
LLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDV
VVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANE
LFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTY
GPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNN
SKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIK
AIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYS
AIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGCYDFD
VHTMKTLKNIISPPWDFR

3D structure

PDB

6q6h Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	K	Y242 Y243 C245 A339 H342 A345 V346 L369 Y373 D401 F403 H406 F413 K443 E445 P446 N449 N450 H453 R456 K457 Y487 L491 F514 M518 M525	Y209 Y210 C212 A306 H309 A312 V313 L336 Y340 D368 F370 H373 F380 K410 E412 P413 N416 N417 H420 R423 K424 Y454 L458 F481 M485 M492

Gene Ontology

	Molecular Function
GO:0005515	protein binding

	Biological Process
GO:0007346	regulation of mitotic cell cycle
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent catabolic process
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0051301	cell division
GO:0051445	regulation of meiotic cell cycle
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0141198	protein branched polyubiquitination

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0072686	mitotic spindle

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6q6h, PDBe:6q6h, PDBj:6q6h
PDBsum	6q6h
PubMed	31455778
UniProt	Q13042\|CDC16_HUMAN Cell division cycle protein 16 homolog (Gene Name=CDC16)

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