Structure of PDB 6pc8 Chain K

Receptor sequence

>6pc8K (length=271) Species: 562 (Escherichia coli) [Search protein sequence]

AVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITT
RHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGER
RYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKG
GQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHM
LRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQ
TKGKKTRSNKRTDKFIVRRRS

3D structure

PDB

6pc8 Synthetic group A streptogramin antibiotics that overcome Vat resistance.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	K	P8 T9 P11 G12 R13 R14 H15 E35 S40 R43 N44 N45 N46 R48 I49 T50 T51 R52 H53 G56 H58 K59 Q60 Y62 R63 Y83 P85 R87 D98 G99 R101 M146 K147 G149 K150 Q153 L154 A155 R156 S157 G159 T160 Y171 L176 R177 S178 E180 R182 H200 M201 G206 K207 A208 G209 R212 W213 R214 R217 P218 T219 V220 R221 T223 A224 M225 N226 P227 V228 D229 H232 G234 G235 E236 R238 N239 F240 G241 K242 H243 P244 T246 W248 Q251 T252 K253 G254 K256 T257 R258 S259 K261 R262 R270 R271	P7 T8 P10 G11 R12 R13 H14 E34 S39 R42 N43 N44 N45 R47 I48 T49 T50 R51 H52 G55 H57 K58 Q59 Y61 R62 Y82 P84 R86 D97 G98 R100 M145 K146 G148 K149 Q152 L153 A154 R155 S156 G158 T159 Y170 L175 R176 S177 E179 R181 H199 M200 G205 K206 A207 G208 R211 W212 R213 R216 P217 T218 V219 R220 T222 A223 M224 N225 P226 V227 D228 H231 G233 G234 E235 R237 N238 F239 G240 K241 H242 P243 T245 W247 Q250 T251 K252 G253 K255 T256 R257 S258 K260 R261 R269 R270

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0032297	negative regulation of DNA-templated DNA replication initiation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990082	DnaA-L2 complex
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6pc8, PDBe:6pc8, PDBj:6pc8
PDBsum	6pc8
PubMed	32968273
UniProt	P60422\|RL2_ECOLI Large ribosomal subunit protein uL2 (Gene Name=rplB)

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