Structure of PDB 6kiz Chain K

Receptor sequence
>6kizK (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
ARAEVHLRKSAFDMFNFLASKHRQARRATSMDLPMPMRFRHLKKTSKEAV
GVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIG
CYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAM
RKIYRGEELTYDYKLPCNCGAKKCRKFLN
3D structure
PDB6kiz Structural basis of nucleosome recognition and modification by MLL methyltransferases.
ChainK
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH K H3839 G3840 R3841 Y3883 F3904 N3906 H3907 C3957 N3958 H58 G59 R60 Y102 F123 N125 H126 C167 N168 BindingDB: IC50=2300nM
BS02 ZN K C3957 N3958 C3959 C167 N168 C169
External links
PDB RCSB:6kiz, PDBe:6kiz, PDBj:6kiz
PDBsum6kiz
PubMed31485071
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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