Structure of PDB 6gwj Chain K

Receptor sequence
>6gwjK (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
PAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRA
VILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWN
KPLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGE
TIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMD
VSFSGILSFIEDVAHRMLATGECTPEDLCFSLQETVFAMLVEITERAMAH
CGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQ
AGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWRD
3D structure
PDB6gwj Defects in t 6 A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome.
ChainK
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG K H109 H113 D294 H108 H112 D293
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity
Biological Process
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
Cellular Component
GO:0000408 EKC/KEOPS complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gwj, PDBe:6gwj, PDBj:6gwj
PDBsum6gwj
PubMed31481669
UniProtQ9NPF4|OSGEP_HUMAN tRNA N6-adenosine threonylcarbamoyltransferase (Gene Name=OSGEP)

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