Structure of PDB 6fvw Chain K

Receptor sequence
>6fvwK (length=384) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SDIYFKLKKLEKEYELLTLQEDYIKDEQRHLKRELKRAQEEVKRIQSVPL
VIGQFLEPIDQNTGIVSSTTGMSYVVRILSTLDRELLKPSMSVALHRHSN
ALVDILPPDSDSSISVMGENEKPDVTYADVGGLDMQKQEIREAVELPLVQ
ADLYEQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTKAAFIRVNGSEFVH
KYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGSDREVQR
ILIELLTQMDGFDQSTNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLR
DRRERRLIFGTIASKMSLAPEADLDSLIIRNDSLSGAVIAAIMQEAGLRA
VRKNRYVILQSDLEEAYATQVKTDNTVDKFDFYK
3D structure
PDB6fvw Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.
ChainK
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP K G176 P215 G216 T217 G218 K219 T220 M221 N319 I352 G380 A381 G132 P171 G172 T173 G174 K175 T176 M177 N275 I308 G336 A337
BS02 ATP K R330 R333 R286 R289
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010604 positive regulation of macromolecule metabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6fvw, PDBe:6fvw, PDBj:6fvw
PDBsum6fvw
PubMed30067984
UniProtP33298|PRS6B_YEAST 26S proteasome regulatory subunit 6B homolog (Gene Name=RPT3)

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