Structure of PDB 6eot Chain K

Receptor sequence
>6eotK (length=832) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKYHKAPHDFMFVKRNDPDGPHSDRIYYL
AMRENTLFYSEIPKTINRAAVLMLSWKPLLDLYSREEELLRERKRIGTVG
IASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIR
MDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARS
AGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIH
VTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELI
QPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPV
EDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIE
FIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAIT
SGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTR
LTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKE
FWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTV
LFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFE
GAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMAL
MQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQA
EKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERH
SIRVPESGEHYELHLLHYLQENLGSRIAALKV
3D structure
PDB6eot Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
ChainK
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y604 S690 Y691 D768 H800
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide K R160 E275 E276 Y669 Q673 V674 K685 W754 S755 V781 W784 Y787 Y791 H865 S866 I867 G873 E877 R95 E210 E211 Y604 Q608 V609 K620 W689 S690 V716 W719 Y722 Y726 H800 S801 I802 G808 E812
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eot, PDBe:6eot, PDBj:6eot
PDBsum6eot
PubMed29382749
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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