Structure of PDB 5y2z Chain K

Receptor sequence
>5y2zK (length=486) Species: 9606 (Homo sapiens) [Search protein sequence]
NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLK
TRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSG
SQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIIS
DKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGA
CLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQD
SQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDG
YSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGN
CGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT
LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSS
KEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHN
3D structure
PDB5y2z Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
ChainK
Resolution2.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA K E242 D325 C433 N436 E10 D93 C201 N204
BS02 CA K E446 C447 N449 F451 E453 E456 D459 E214 C215 N217 F219 E221 E224 D227
BS03 CA K D511 I512 E514 N526 I527 D279 I280 E282 N294 I295
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5y2z, PDBe:5y2z, PDBj:5y2z
PDBsum5y2z
PubMed29670100
UniProtQ9P0K1|ADA22_HUMAN Disintegrin and metalloproteinase domain-containing protein 22 (Gene Name=ADAM22)

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