Structure of PDB 5lf6 Chain K

Receptor sequence
>5lf6K (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAA
DCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTM
ICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVE
QAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYS
3D structure
PDB5lf6 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
ChainK
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide K T5 A24 T25 V35 K37 G51 A53 Y173 T1 A20 T21 V31 K33 G47 A49 Y169
BS02 MG K T168 D171 A172 S174 T164 D167 A168 S170
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lf6, PDBe:5lf6, PDBj:5lf6
PDBsum5lf6
PubMed27493187
UniProtP28074|PSB5_HUMAN Proteasome subunit beta type-5 (Gene Name=PSMB5)

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