Structure of PDB 5lcw Chain K

Receptor sequence
>5lcwK (length=493) Species: 9606 (Homo sapiens) [Search protein sequence]
NLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTA
QYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLSIKSSICL
LRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKEL
LESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVV
VSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANEL
FYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYG
PAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNS
KLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKA
IGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSA
IGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYI
3D structure
PDB5lcw Molecular basis of APC/C regulation by the spindle assembly checkpoint.
ChainK
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0072686 mitotic spindle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lcw, PDBe:5lcw, PDBj:5lcw
PDBsum5lcw
PubMed27509861
UniProtQ13042|CDC16_HUMAN Cell division cycle protein 16 homolog (Gene Name=CDC16)

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