Structure of PDB 5l5p Chain K

Receptor sequence
>5l5pK (length=211) Species: 9606,559292 [Search protein sequence]
TTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAA
DCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSM
ICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVE
DALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVK
EEEGSFNNVIG
3D structure
PDB5l5p A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i.
ChainK
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T1 D17 R19 K33 G47 S130 D167 S170
Catalytic site (residue number reindexed from 1) T1 D17 R19 K33 G47 S130 D167 S170
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 79L K T1 R19 A20 S21 V31 K33 M45 G47 A49 Y169 T1 R19 A20 S21 V31 K33 M45 G47 A49 Y169
BS02 MG K A164 D167 A168 S170 A164 D167 A168 S170
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5l5p, PDBe:5l5p, PDBj:5l5p
PDBsum5l5p
PubMed27789522
UniProtP28062|PSB8_HUMAN Proteasome subunit beta type-8 (Gene Name=PSMB8);
P30656|PSB5_YEAST Proteasome subunit beta type-5 (Gene Name=PRE2)

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