Structure of PDB 5dst Chain K

Receptor sequence
>5dstK (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
SYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMF
AAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEK
VDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIED
RQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEV
DIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAP
DAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDF
KGQLCETSVSNDYKMR
3D structure
PDB5dst Novel helical assembly in arginine methyltransferase 8
ChainK
Resolution2.963 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D92 E185 E194 H334
Catalytic site (residue number reindexed from 1) D14 E107 E116 H256
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH K Y80 M89 R95 G119 I124 E141 C142 K168 V169 E170 M196 T199 Y2 M11 R17 G41 I46 E63 C64 K90 V91 E92 M118 T121
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5dst, PDBe:5dst, PDBj:5dst
PDBsum5dst
PubMed26876602
UniProtQ9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 8 (Gene Name=PRMT8)

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