Structure of PDB 3lnz Chain K

Receptor sequence
>3lnzK (length=83) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
3D structure
PDB3lnz Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
ChainK
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide K L54 L57 G58 I61 M62 Q72 H73 V93 H96 Y100 L29 L32 G33 I36 M37 Q47 H48 V68 H71 Y75
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3lnz, PDBe:3lnz, PDBj:3lnz
PDBsum3lnz
PubMed20226197
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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