Structure of PDB 3fa4 Chain K

Receptor sequence
>3fa4K (length=280) Species: 5061 (Aspergillus niger) [Search protein sequence]
VTAATSLRRALENPDSFIVAPGVYDGLSARVALSAGFDALYMTGAGTAAS
VHGQADLGICTLNDMRANAEMISNISPSTPVIADADTGYGGPIMVARTTE
QYSRSGVAAFHIEDQVQILVDTDTYVTRIRAAVQARQRIGSDIVVIARTD
SLQTHGYEESVARLRAARDAGADVGFLEGITSREMARQVIQDLAGWPLLL
NMVEHGATPSISAAEAKEMGFRIIIFPFAALGPAVAAMREAMEKLKRDGI
PGLDKEMTPQMLFRVCGLDESMKVDAQAGG
3D structure
PDB3fa4 Structure and function of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily member.
ChainK
Resolution2.18 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y44 T46 G47 A48 D59 D87 D89 H114 E116 R161 E191 N214 T221 S223
Catalytic site (residue number reindexed from 1) Y41 T43 G44 A45 D56 D84 D86 H111 E113 R148 E178 N201 T208 S210
Enzyme Commision number 4.1.3.30: methylisocitrate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG K D87 D89 D84 D86
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3fa4, PDBe:3fa4, PDBj:3fa4
PDBsum3fa4
PubMed19133276
UniProtQ2L887

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