Structure of PDB 2qub Chain K

Receptor sequence

>2qubK (length=615) Species: 615 (Serratia marcescens) [Search protein sequence]

SHMGIFSYKDLDENASKALFSDALAISTYAYHNIDNGFDEGYHQTGFGLG
LPLTLITALIGSTQSQGGLPGLPWNPDSEQAAQEAVNNAGWSVISATQLG
YAGKTDARGTYYGETAGYTTAQAEVLGKYDSEGNLTAIGISFRGTSGPRE
SLIGDTIGDVINDLLAGFGPKGYADGYTLKAFGNLLGDVAKFAQAHGLSG
EDVVVSGHSLGGLAVNSMAAQSDANWGGFYAQSNYVAFASPTQYEAGGKV
INIGYENDPVFRALDGTSLTLPSLGVHDAPHTSATNNIVNFNDHYASDAW
NLLPFSILNIPTWLSHLPFFYQDGLMRVLNSEFYSLTDKDSTIIVSNLSN
VTRGNTWVEDLNRNAETHSGPTFIIGSDGNDLIKGGKGNDYLEGRDGDDI
FRDAGGYNLIAGGKGHNIFDTQQALKNTEVAYDGNTLYLRDAKGGITLAD
DISTLRSKETSWLIFNKEVDHQVTAAGLKSDSGLKAYAAATGGDGDDVLQ
ARSHDAWLFGNAGNDTLIGHAGGNLTFVGGSGDDILKGVGNGNTFLFSGD
FGRDQLYGFNASDKLVFIGTEGASGNIRDYATQQNDDLVLAFGHSQVTLI
GVSLDHISTDQVVLA

3D structure

PDB

2qub A calcium-gated lid and a large beta-roll sandwich are revealed by the crystal structure of extracellular lipase from Serratia marcescens.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.1.3: triacylglycerol lipase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	K	G491 G493 D495 G508 N509 A510 D513	G493 G495 D497 G510 N511 A512 D515
BS02	CA	K	G528 S529 G530 D532 F549 D552	G530 S531 G532 D534 F551 D554
BS03	CA	K	N509 A510 G511 D513 G527 G528 S529 D532	N511 A512 G513 D515 G529 G530 S531 D534
BS04	CA	K	G384 G386 D388 D401 G403 N406	G386 G388 D390 D403 G405 N408
BS05	CA	K	R393 D394 G395 D397 G410 K412 N415	R395 D396 G397 D399 G412 K414 N417
BS06	CA	K	S375 G377 D379 G392 R393 D394 D397	S377 G379 D381 G394 R395 D396 D399
BS07	CA	K	E254 D276 N284 N285	E256 D278 N286 N287
BS08	CA	K	T118 Q120 S144 D153 D157	T120 Q122 S146 D155 D159

Gene Ontology

	Molecular Function
GO:0004806	triacylglycerol lipase activity
GO:0005509	calcium ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:2qub, PDBe:2qub, PDBj:2qub
PDBsum	2qub
PubMed	17728256
UniProt	Q59933

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