Structure of PDB 2aaz Chain K

Receptor sequence
>2aazK (length=299) Species: 5207 (Cryptococcus neoformans) [Search protein sequence]
PDHEEYQYLDLIRRIINVGEVRPDRTGTGTVALFAPPSFRFSLADNTLPL
LTTKRVFLRGVIAELLWFVSGCTDAKMLSSQGVGIWDGNGSKEFLEKVGL
GHRREGDLGPVYGFQWRHFGAEYTDADGDYKGKGVDQLQRVIDTIKNNPT
DRRIILSAWNPKDLPLMALPPCHMFCQFFVSLPPPGSKPKLSCLMYQRSC
DLGLGVPFNIASYALLTHMIALITDTEPHEFILQMGDAHVYRDHVEPLKT
QLEREPRDFPKLKWARSKEEIGDIDGFKVEDFVVEGYKPWGKIDMKMSA
3D structure
PDB2aaz The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.
ChainK
Resolution2.08 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E79 W101 Y127 C187 R216 D219
Catalytic site (residue number reindexed from 1) E64 W86 Y112 C172 R198 D201
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP K R40 C187 Q215 R216 S217 D219 N227 H257 Y259 R25 C172 Q197 R198 S199 D201 N209 H239 Y241
BS02 UMP K R167 R168 R152 R153
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2aaz, PDBe:2aaz, PDBj:2aaz
PDBsum2aaz
PubMed16204883
UniProtP0CS12|TYSY_CRYNJ Thymidylate synthase (Gene Name=TMP1)

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