Structure of PDB 1iw7 Chain K

Receptor sequence
>1iw7K (length=229) Species: 274 (Thermus thermophilus) [Search protein sequence]
MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPLRRILLSSIPG
TAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLKELVVRFLNPSLQTVTLL
LKAEGPKEVKARDFLPVADVEIMNPDLHIATLEEGGRLNMEVRVDRGVGY
VPAEKHGIKDRINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIW
TDGSVTPLEALNQAVEILREHLTYFSNPQ
3D structure
PDB1iw7 Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution
ChainK
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG K K159 D160 R161 I162 K159 D160 R161 I162
BS02 MG K L45 S172 L45 S172
BS03 MG K E29 R30 E29 R30
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1iw7, PDBe:1iw7, PDBj:1iw7
PDBsum1iw7
PubMed12000971
UniProtQ9Z9H6|RPOA_THETH DNA-directed RNA polymerase subunit alpha (Gene Name=rpoA)

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