Structure of PDB 7wtm Chain JL

Receptor sequence
>7wtmJL (length=283) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
QHILKNPLVAQGIVDKAQIRPSDVVLEVGPGTGNLTVRILEQAKNVVAVE
MDPRMAAELTKRVRGTPVEKKLEIMLGDFMKTELPYFDICISNTPYQISS
PLVFKLINQPRPPRVSILMFQREFALRLLARPGDSLYCRLSANVQMWANV
THIMKVGKNNFRPPPQVESSVVRLEIKNPRPQVDYNEWDGLLRIVFVRKN
RTISAGFKSTTVMDILEKNYKTFLAMNNEMVDDTKGSMHDVVKEKIDTVL
KETDLGDKRAGKCDQNDFLRLLYAFHQVGIHFS
3D structure
PDB7wtm In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation.
ChainJL
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.183: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna JL Y131 Q132 Q156 E158 F159 Q201 V202 R228 R233 N235 R236 T237 A240 K243 T245 T246 R294 Y96 Q97 Q121 E123 F124 Q166 V167 R193 R198 N200 R201 T202 A205 K208 T210 T211 R259
Gene Ontology
Molecular Function
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0052909 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
Biological Process
GO:0000154 rRNA modification
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030686 90S preribosome
GO:0030688 preribosome, small subunit precursor

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wtm, PDBe:7wtm, PDBj:7wtm
PDBsum7wtm
PubMed36263816
UniProtP41819|DIM1_YEAST Dimethyladenosine transferase (Gene Name=DIM1)

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