Structure of PDB 7uck Chain JJ

Receptor sequence

>7uckJJ (length=185) Species: 9986 (Oryctolagus cuniculus)

PVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLA
KIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLK
IEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRL
DSQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAG

3D structure

• PDB: 7uck Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
• Chain: JJ
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	JJ	P2 V3 R5 W7 V8 C9 R10 K11 T12 T15 R17 R18 F20 R38 N39 K40 R41 R45 F72 E73 R79 R80 R83 S122 H125 R127 R131 Q132 R133 H134 R138 N143 I144 F147 I148 R150 R162 P164 Y165 G171 R172 V173 K174 N177	P1 V2 R4 W6 V7 C8 R9 K10 T11 T14 R16 R17 F19 R37 N38 K39 R40 R44 F71 E72 R78 R79 R82 S121 H124 R126 R130 Q131 R132 H133 R137 N142 I143 F146 I147 R149 R161 P163 Y164 G170 R171 V172 K173 N176

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0043226 organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7uck, PDBe:7uck, PDBj:7uck
• PDBsum: 7uck
• PubMed: 35679869
• UniProt: B7NZS8|RS9_RABIT Small ribosomal subunit protein uS4 (Gene Name=RPS9)