Structure of PDB 8i7o Chain JF

Receptor sequence
>8i7oJF (length=427) Species: 10090 (Mus musculus) [Search protein sequence]
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVY
YNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK
TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQD
3D structure
PDB8i7o In-cell structural insight into the stability of sperm microtubule doublet
ChainJF
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP JF G10 Q11 C12 Q15 N99 S138 G141 G142 T143 G144 Y222 G10 Q11 C12 Q15 N99 S138 G141 G142 T143 G144 Y222
BS02 GTP JF Q245 N247 K252 Q245 N247 K252
Gene Ontology
Molecular Function
GO:0003725 double-stranded RNA binding
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process
GO:0030317 flagellated sperm motility
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005879 axonemal microtubule
GO:0015630 microtubule cytoskeleton
GO:0031514 motile cilium
GO:0036126 sperm flagellum
GO:0043209 myelin sheath
GO:0045171 intercellular bridge
GO:0045298 tubulin complex
GO:0072686 mitotic spindle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i7o, PDBe:8i7o, PDBj:8i7o
PDBsum8i7o
PubMed37989994
UniProtP68372|TBB4B_MOUSE Tubulin beta-4B chain (Gene Name=Tubb4b)

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