Structure of PDB 8wqc Chain J

Receptor sequence
>8wqcJ (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
FEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVA
WGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQK
3D structure
PDB8wqc cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1
ChainJ
Resolution3.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
2.3.2.32: cullin-RING-type E3 NEDD8 transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN J C56 H82 C35 H61
BS02 ZN J C42 C45 H80 C83 C21 C24 H59 C62
BS03 ZN J C75 H77 C94 D97 C54 H56 C73 D76
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8wqc, PDBe:8wqc, PDBj:8wqc
PDBsum8wqc
PubMed38670995
UniProtP62877|RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (Gene Name=RBX1)

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