Structure of PDB 8r08 Chain J

Receptor sequence
>8r08J (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
PEIEWWDSYIIFGITNLVEHPAQLNPPVTLGVYLTKKEQKKLRRQTRREA
QKELQEKVRLGLMPPPEPKDISQGVHISVYRVRNLSNPAKKFKIEANAGQ
LYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDTNKCVLVWEGT
AKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD
3D structure
PDB8r08 Structural insights into the cross-exon to cross-intron spliceosome switch
ChainJ
Resolution6.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna J R453 P474 K475 P554 A555 F558 K559 A562 N563 R47 P68 K69 P88 A89 F92 K93 A96 N97
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r08, PDBe:8r08, PDBj:8r08
PDBsum8r08
PubMed38778104
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

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