Structure of PDB 8qns Chain J

Receptor sequence

>8qnsJ (length=437) Species: 10090 (Mus musculus)

PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKE
LWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAVL
TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVK
SRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQASGI
EVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGR
LLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQ
ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWH
QSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKEDYGKGVIFYLRDKVVVG
IVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHE

3D structure

• PDB: 8qns Structural characterization of the interaction between apoptosis inducing factor (AIF) and CHCHD4.
• Chain: J
• Resolution: 3.206 Å

Enzymatic activity

• Enzyme Commision number: 1.6.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	J	P344 Y346 S499 S500 L501 T503 V504 G505 V506 F507 E557 Y559	P217 Y219 S372 S373 L374 T376 V377 G378 V379 F380 E383 Y385
BS02	FAD	J	G137 G138 G139 T140 A141 E163 R171 P172 K176 K231 V232 T259 G260 F283 R284 E404 D437 E452 H453 H454 W482	G10 G11 G12 T13 A14 E36 R44 P45 K49 K104 V105 T132 G133 F156 R157 E277 D310 E325 H326 H327 W355
BS03	NAD	J	L266 R284 G306 G307 G308 F309 L310 E313 E335 K341 A396 V397 G398 L399 E452 H453	L139 R157 G179 G180 G181 F182 L183 E186 E208 K214 A269 V270 G271 L272 E325 H326

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0046983 protein dimerization activity

External links

• PDB: RCSB:8qns, PDBe:8qns, PDBj:8qns
• PDBsum: 8qns
• UniProt: Q9Z0X1|AIFM1_MOUSE Apoptosis-inducing factor 1, mitochondrial (Gene Name=Aifm1)