Structure of PDB 8jfk Chain J

Receptor sequence

>8jfkJ (length=1033) Species: 9606 (Homo sapiens)

DNETLWDKLDHYYRIVKSTLLLYQSPTTGLFPTKTCGGDQKAKIQDSLYC
AAGAWALALAYRRIDDDKGRTHELEHSAIKCMRGILYCYMRQADKVQQFK
QDPRPTTCLHSVFNVHTGDELLSYEEYGHLQINAVSLYLLYLVEMISSGL
QIIYNTDEVSFIQNLVFCVERVYRVPDFGVWERGSKYNNGSTELHSSSVG
LAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLLPRESRSH
NTDAALLPCISYPAFALDDEVLFSQTLDKVVRKLKGKYGFKRFLRDGYRT
SLEDPNRCYYKPAEIKLFDGIECEFPIFFLYMMIDGVFRGNPKQVQEYQD
LLTPVLHHTTEGYPVVPKYYYVPADFVEYEKNNPGSQKRFPSNCGRDGKL
FLWGQALYIIAKLLADELISPKDIDPVQRYVPLKDQRNVSMRFSNQGPLE
NDLVVHVALIAESQRLQVFLNTYGIQTQTPQQVEPIQIWPQQELVKAYLQ
LGINEKLGLSGRPDRPIGCLGTSKIYRILGKTVVCYPIIFDLSDFYMSQD
VFLLIDDIKNALQFIKQYWKMHGRPLFLVLIREDNIRGSRFNPILDMLAA
LKKGIIGGVKVHVDRLQTLISGAVVEQLDFLRISDTEELPEFKSFEELEG
QQPDVNISEWKDKPTHEILQKLNDCSCLASQAILLGILLKREGPNFITKE
GTVSDHIERVYRRAGSQKLWLAVRYGAAFTQKFSSSIAPHITTFLVHGKQ
VTLGAFGHEEEVISNPLSPRVIQNIIYYKCNTHDEREAVIQQELVIHIGW
IISNNPELFSGMLKIRIGWIIHAMEYELQIRGGDKPALDLYQLSPSEVKQ
LLLDILQPQQNGRCWLNRRQIDGSLNRTPTGFYDRVWQILERTPNGIIVA
GKHLPQQPTLSDMTMYEMNFSLLVEDTLGNIDQPQYRQIVVELLMVVSIV
LERNPELEFQDKVDLDRLVKEAFNEFQKDQSRLKEIEKQDDMTSFYNTPP
LGKRGTCSYLTKAVMNLLLEGEVKPNNDDPCLI

3D structure

• PDB: 8jfk Architecture and activation of human muscle phosphorylase kinase
• Chain: J
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAR	J	N1013 E1015 M1074 C1090	N954 E956 M1015 C1031
BS02	FAR	J	I1008 R1012 L1060 C1066 T1070	I949 R953 L1001 C1007 T1011

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005516 calmodulin binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0005977 glycogen metabolic process
• GO:0006091 generation of precursor metabolites and energy

Cellular Component

• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0005964 phosphorylase kinase complex

External links

• PDB: RCSB:8jfk, PDBe:8jfk, PDBj:8jfk
• PDBsum: 8jfk
• PubMed: 38548794
• UniProt: Q93100|KPBB_HUMAN Phosphorylase b kinase regulatory subunit beta (Gene Name=PHKB)