Structure of PDB 8jce Chain J

Receptor sequence
>8jceJ (length=453) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
DPVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDAANARAFSHLAIKLI
EQEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLA
SAAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQ
DVYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWAD
EQVLKAKNIGLCSTDLTEGRRGKLSIMRGKKLEPCDRVLFSVGSTLYPES
RKLLKSWHLPSVFHLKGKLSFTCRCDTVVSCEGYVVKRITMSPGLYGKTT
GYAVTHHADGFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVT
PEDAQKLLVGLNQRTNTMKNYMIPVVAQAFSKWAKECRKDMEDEKLLGVR
ERTWAFKKQKTHTVYKRPDTQSIQKVQAEFDSFVWSSGLSIPLRTRIKWL
LSK
3D structure
PDB8jce Chikungunya virus Non-structural Protein 1 is a versatile RNA capping and decapping enzyme.
ChainJ
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN J H79 E129 C134 C141 H78 E128 C133 C140
BS02 SAH J G65 R70 P83 D89 D138 G64 R69 P82 D88 D137
BS03 YG4 J R41 K99 Y154 Y248 E250 R40 K98 Y153 Y247 E249
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008174 mRNA methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0016556 mRNA modification

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8jce, PDBe:8jce, PDBj:8jce
PDBsum8jce
PubMed37918803
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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