Structure of PDB 8j4z Chain J

Receptor sequence
>8j4zJ (length=541) Species: 9606 (Homo sapiens) [Search protein sequence]
YHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKAR
ALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITG
IGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVD
SGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAY
VPAMADENIIVRKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGV
SDHWALDDHHALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVG
ANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFARIFGYPVGIVGN
NGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAKDG
AKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISV
MGGEQAANVLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYS
SARVWDDGIIDPADTRLVLGLSFSAALNAPIEKTDFGIFRM
3D structure
PDB8j4z Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate
ChainJ
Resolution2.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.4: methylcrotonoyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BTI J G406 F407 Y445 A447 G384 F385 Y423 A425
BS02 TW3 J R78 K141 G142 A144 G174 G175 A176 Y177 F191 T217 A218 G219 R56 K119 G120 A122 G152 G153 A154 Y155 F169 T195 A196 G197
BS03 TW3 J I485 Q489 I463 Q467
BS04 BTI J L241 L246 L219 L224
Gene Ontology
Molecular Function
GO:0004485 methylcrotonoyl-CoA carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006552 L-leucine catabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0015936 coenzyme A metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:1905202 methylcrotonoyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j4z, PDBe:8j4z, PDBj:8j4z
PDBsum8j4z
PubMed
UniProtQ9HCC0|MCCB_HUMAN Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (Gene Name=MCCC2)

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