Structure of PDB 8it1 Chain J

Receptor sequence

>8it1J (length=450) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]

MRNKIFISHATPEDDDFTRWLSLKLIGLGYEVWCDILFLDKGVDFWSTIE
KEIRENTCKFLIVSSTAGNKREGVLKELAVATKVKKHLQDDMFIIPLAID
ENLSYDDINIEIVRLNAIDFKKSWAKGLQDLLDAFEKQNVPKKPPDHSKS
NLLYQQIFLHDKQAIEKEETYDSNWFPIISFPNELRFHRYDWRLPKQFDV
RTLAFPAIRYKEYLCTFAWEYDFIHQLPKTETYNGQESIRISTSDILSGR
YDTDFIRNYECQRLIVQLINKAFELRMKDKNVREYQMSKTFAYWIEKGKL
EKDKFEKIKLVGKQKNKYWHFGISAAGKLYPSPVLMVSSHIIFTMDGINL
IKSKSIQHSSRRKQGKNWWNDKWREKLLAFIRFLSDDQNAIYLNVGSEEK
ILISNKPLKFFGKMSYVTPSEVTLEEESVLADINNFEEDTEDLDELEDIE

3D structure

PDB

8it1 Nucleic acid-triggered NADase activation of a short prokaryotic Argonaute.

Chain

Resolution

3.41 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	J	K271 K328 S355 H358 S359 R362 K363 K366 A431 N434 N435 T440 E441 D442 E445	K271 K328 S355 H358 S359 R362 K363 K366 A431 N434 N435 T440 E441 D442 E445
BS02	rna	J	K196 Y210 K211 Y259 Y285 M287 H340 K354 Q357 H358 R361 R362 N434 E438	K196 Y210 K211 Y259 Y285 M287 H340 K354 Q357 H358 R361 R362 N434 E438

Gene Ontology

	Biological Process
GO:0007165	signal transduction

View graph for
Biological Process

External links

PDB	RCSB:8it1, PDBe:8it1, PDBj:8it1
PDBsum	8it1
PubMed	37783228
UniProt	A0A1I7NFG5

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