Structure of PDB 8fno Chain J

Receptor sequence

>8fnoJ (length=47) Species: 9606,11698

NFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKII

3D structure

• PDB: 8fno Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
• Chain: J
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	J	R228 R263	R7 R42
BS02	dna	J	W243 E246 G247 A248 R263	W22 E25 G26 A27 R42

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:8fno, PDBe:8fno, PDBj:8fno
• PDBsum: 8fno
• PubMed: 37478179
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol);
  P42166