Structure of PDB 8cef Chain J

Receptor sequence

>8cefJ (length=88) Species: 10090 (Mus musculus)

PKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEIT
KRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYK

3D structure

• PDB: 8cef Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA.
• Chain: J
• Resolution: 2.486 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	J	E97 A98 R105 R128 K129 Q132 R135 R155 G156 G157 R158 K160	E23 A24 R31 R54 K55 Q58 R61 R81 G82 G83 R84 K86
BS02	dna	J	G88 Y89 H90 Y91 K100 K104 K129 V149 R150 R153 V154 R155 R158 Y161	G14 Y15 H16 Y17 K26 K30 K55 V75 R76 R79 V80 R81 R84 Y87
BS03	ZN	J	C79 C82 C99	C5 C8 C25
BS04	ZN	J	C115 C121 C131 C134	C41 C47 C57 C60

Gene Ontology

Molecular Function

• GO:0003700 DNA-binding transcription factor activity
• GO:0008270 zinc ion binding
• GO:0043565 sequence-specific DNA binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:8cef, PDBe:8cef, PDBj:8cef
• PDBsum: 8cef
• PubMed: 37503845
• UniProt: O08580|ERR1_MOUSE Steroid hormone receptor ERR1 (Gene Name=Esrra)