Structure of PDB 8bto Chain J

Receptor sequence
>8btoJ (length=473) Species: 1053222 (Bacillus cereus MSX-D12) [Search protein sequence]
MKMNPIVELFIKDFTKEVMEENAAIFAGAGLSMSVGYVSWAKLLEPIAQE
IGLDVNKENDLVSLAQYYCNENQGNRGRINQIILDEFSRKVDLTENHKIL
ARLPIHTYWTTAYDRLIEKALEEENKIADVKYTVKQLATTKVKRDAVVYK
MHGDVEHPSEAVLIKDDYEKYSIKMDPYIKALSGDLVSKTFLFVGFSFTD
PNLDYILSRVRSAYERDQRRHYCLIKKEERRPDELEADFEYRVRKQELFI
SDLSRFNIKTIVLNNYNEITEILQRIENNIKTKTVFLSGSAVEYNHWETE
HAEQFIHQLSKELIRKDFNIVSGFGLGVGSFVINGVLEELYMTIDDDRLI
LRPFPQGKKGEEQWDKYRRDMITRTGVSIFLYGNKIDKGQVVKAKGVQSE
FNISFEQNNYVVPVGATGYIAKDLWNKVNEEFETYYPGADARMKKLFGEL
NNEALSIEELINTIIEFVEILSN
3D structure
PDB8bto Activation of Thoeris antiviral system via SIR2 effector filament assembly
ChainJ
Resolution2.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.5: NAD(+) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OJC J G289 S290 G325 L326 F357 Q359 W367 R371 K388 A397 G399 E403 G289 S290 G325 L326 F354 Q356 W364 R368 K385 A394 G396 E400
BS02 NAD J A29 G30 M33 G195 F196 S197 Y266 A29 G30 M33 G195 F196 S197 Y266
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016787 hydrolase activity
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bto, PDBe:8bto, PDBj:8bto
PDBsum8bto
PubMed38383786
UniProtJ8G6Z1|THSA_BACCS NAD(+) hydrolase ThsA (Gene Name=thsA)

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