Structure of PDB 7w5a Chain J

Receptor sequence
>7w5aJ (length=567) Species: 9606 (Homo sapiens) [Search protein sequence]
VKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKR
KTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITL
WLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAG
ARQVFERWMEWQPEEQAWHSYINFELRYKEVDRARTIYERFVLVHPDVKN
WIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKE
FERVRVIYKYALDRISKQELFKNYTIFEKKFGDRRGKRRFQYEEEVKANP
HNYDAWFDYLRLVESDAEAEAVREVNVPPIQEKRHWKRYIYNYALYEELE
AKDPERTRQASLELIPHKKAKMWILYAQFEIRQKARRALGTSIGKCPKKL
FKVYIELELQLREFDREKFLEFGPENCTSWIELETILGDIDRARLAISQP
RLDMPEVLWIDFEIEQEETERTRNYRRLLQRTQHVKVIFAFELSSGKEGS
LTKCRQINKTMRNCEEKEERLMLLESFEEEFGTASDKERVDKLMEKVKKR
RKVQTDDGSDAGWEEYF
3D structure
PDB7w5a Mechanism of exon ligation by human spliceosome.
ChainJ
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna J R236 K237 I242 K247 N275 T277 K315 R58 K59 I64 K69 N97 T99 K137
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0071014 post-mRNA release spliceosomal complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w5a, PDBe:7w5a, PDBj:7w5a
PDBsum7w5a
PubMed35705093
UniProtQ9BZJ0|CRNL1_HUMAN Crooked neck-like protein 1 (Gene Name=CRNKL1)

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