Structure of PDB 7vp9 Chain J

Receptor sequence
>7vp9J (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
PLIPIVVEQTERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSE
SNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLL
AAGTPGMRHSLPNSRIMIHQPIQAEEIMKLKKQLYNIYAKHTKQSLQVIE
SAMERDRYMSPMEAQEFGILDKVLVHPP
3D structure
PDB7vp9 Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma.
ChainJ
Resolution2.552 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7SR J I75 R78 L79 E82 W146 I16 R19 L20 E23 W87
BS02 MG J M136 I139 M77 I80
BS03 7SR J L104 F105 Q107 S108 Y138 L45 F46 Q48 S49 Y79
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7vp9, PDBe:7vp9, PDBj:7vp9
PDBsum7vp9
PubMed35905743
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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