Structure of PDB 7syr Chain J

Receptor sequence

>7syrJ (length=206) Species: 9986 (Oryctolagus cuniculus)

GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCI
VLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDE
RKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRK
IKARKG

3D structure

• PDB: 7syr Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
• Chain: J
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	J	G2 I3 R5 N7 H9 K10 R12 T14 R18 K19 Y21 K23 K24 R25 K26 Y27 L29 R31 R42 I43 H44 R47 R49 G50 N52 K53 K54 Y55 R56 L58 R59 N64 C71 T73 S86 N87 V97 K98 N99 K143 I145 K147 R178 Q181 R184 D186 G187	G1 I2 R4 N6 H8 K9 R11 T13 R17 K18 Y20 K22 K23 R24 K25 Y26 L28 R30 R41 I42 H43 R46 R48 G49 N51 K52 K53 Y54 R55 L57 R58 N63 C70 T72 S85 N86 V96 K97 N98 K142 I144 K146 R177 Q180 R183 D185 G186

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7syr, PDBe:7syr, PDBj:7syr
• PDBsum: 7syr
• PubMed: 35822879
• UniProt: G1TJW1|RS8_RABIT Small ribosomal subunit protein eS8 (Gene Name=RPS8)