Structure of PDB 7sym Chain J

Receptor sequence

>7symJ (length=206) Species: 9986 (Oryctolagus cuniculus)

GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCI
VLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDE
RKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRK
IKARKG

3D structure

• PDB: 7sym Comprehensive structural overview of the HCV IRES-mediated translation initiation pathway
• Chain: J
• Resolution: 4.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	J	G2 I3 R5 D6 K10 R11 R12 K13 T14 R18 K19 Y21 K23 K24 R25 K26 Y27 L29 R31 A33 R41 R42 I43 H44 T45 R47 V48 R49 G50 K54 Y55 N64 C71 C72 T73 R74 S86 N87 K98 N99 K143 I145 K147 K148 Y149 S177 R178 Q181 R184 D186	G1 I2 R4 D5 K9 R10 R11 K12 T13 R17 K18 Y20 K22 K23 R24 K25 Y26 L28 R30 A32 R40 R41 I42 H43 T44 R46 V47 R48 G49 K53 Y54 N63 C70 C71 T72 R73 S85 N86 K97 N98 K142 I144 K146 K147 Y148 S176 R177 Q180 R183 D185

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7sym, PDBe:7sym, PDBj:7sym
• PDBsum: 7sym
• UniProt: G1TJW1|RS8_RABIT Small ribosomal subunit protein eS8 (Gene Name=RPS8)